Association of genetic ancestry with molecular tumor profiles in colorectal cancer
Molecular differences in CRC tumor mutation frequencies and gene expression that may underlie observed differences by race and ethnicity were identified. The association of AFR ancestry with increased KRAS mutations aligns with higher CMS3 subtype rates in NH Black patients. The increase of indeterminate CMS in Hispanic/Latino patients suggests that subtype classification methods could benefit from enhanced patient diversity.
Authors
- Nina Niu Sanford (ORCID: https://orcid.org/0000-0001-7840-5700)
- Yannick Pouliot (ORCID: https://orcid.org/0000-0002-0344-1923)
- Francisco M. De La Vega (ORCID: https://orcid.org/0000-0002-9228-2097)
- Brooke Rhead
- Justin Guinney (ORCID: https://orcid.org/0000-0003-1477-1888)
- David Hein (ORCID: https://orcid.org/0000-0002-8625-9528)
Institutions
- Southwestern Medical Center (US)
- Tempus Labs (United States) (US)
- The University of Texas Southwestern Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Genome Medicine
- Published
- 2024-08-13
- DOI
- https://doi.org/10.1186/s13073-024-01373-w
- Citations
- 13
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 5.52