Gene Electrotransfer via Conductivity‐Clamped Electric Field Focusing Pivots Sensori‐Motor DNA Therapeutics: “A Spoonful of Sugar Helps the Medicine Go Down” (Adv. Sci. 30/2024)
Vector‐Free Gene Augmentation Therapy In article number 2401392, Jeremy L. Pinyon, Gary D. Housley, and coworkers describe ‘conductivityclamped’ gene electrotransfer (CC‐GET) which broadly enables vector‐free nucleic acid therapeutics. In preclinical studies, delivery of neurotrophin‐encoding plasmid DNA to the deafened cochlea drove auditory nerve regeneration. In the brain, CC‐GET enabled focal expression of photo‐activated ion channels that modulated neural excitability relevant to treatment of Parkinson's Disease. [Image: see text]
Authors
- John Power (ORCID: https://orcid.org/0000-0002-2478-8416)
- Matthias Klugmann (ORCID: https://orcid.org/0000-0003-0574-612X)
- Andrew K. Wise (ORCID: https://orcid.org/0000-0001-9715-8784)
- David M. Housley (ORCID: https://orcid.org/0000-0002-2484-7148)
- Cherylea J. Browne (ORCID: https://orcid.org/0000-0001-6758-685X)
- Ya Lang Enke (ORCID: https://orcid.org/0000-0002-0124-7481)
- Gary D. Housley (ORCID: https://orcid.org/0000-0002-8413-588X)
- James B. Fallon (ORCID: https://orcid.org/0000-0003-2686-3886)
- John Y. Lin (ORCID: https://orcid.org/0000-0002-1723-4597)
- Daniel Scherman (ORCID: https://orcid.org/0000-0003-1207-1298)
- Catherine S. Birman (ORCID: https://orcid.org/0000-0002-6323-773X)
- Nigel Hamilton Lovell (ORCID: https://orcid.org/0000-0003-1637-1079)
- David McAlpine (ORCID: https://orcid.org/0000-0001-5467-6725)
- Corinne Marie (ORCID: https://orcid.org/0000-0001-9619-5700)
- Robert K. Shepherd (ORCID: https://orcid.org/0000-0002-4239-3362)
- Paul Carter (ORCID: https://orcid.org/0000-0003-1634-7300)
- Robert D. Gay (ORCID: https://orcid.org/0000-0002-0774-5342)
- Edward N. Crawford (ORCID: https://orcid.org/0000-0002-2158-1962)
- Georg von Jonquières (ORCID: https://orcid.org/0000-0002-7423-3355)
- Catherine McMahon (ORCID: https://orcid.org/0000-0001-8124-1399)
- Amr Al Abed (ORCID: https://orcid.org/0000-0002-5560-4771)
- Jeremy L. Pinyon (ORCID: https://orcid.org/0000-0001-6261-3927)
- J. Patrick
- Waikong Lai
Publication Details
- Journal
- Advanced Science
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/advs.202470180
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00