The Potential of Lectins and their Recognized Glycoconjugates in the Human Body

The modern concepts of lectins and glycoconjugates binding to them, the features and patterns of their interaction, the protective role and potential in the human body are summarized. The analysis of terms, approaches to classifications of lectins is carried out. The features of natural and synthetic glycoconjugates, recognized and bound by lectins, in symbiotic relationships, in innate immunity at the reception level are emphasized. The levels of specificity of lectins are considered. There is a need to expand research on the glycoconjugate specificity of lectins and their systems, to assess the communication potential of glycoconjugates in relation to any protein combinations and systems as lectins. The participation of lectin and glycoconjugate systems in signal transmission and communication is noted. Lectins manifest themselves as basic for superstructure glycoconjugate effectors in soluble and solid cell phases in cascade directed assemblies forming the interactome network. Lectins and glycoconjugates, as inextricably co-functioning, are promising in biology, medicine and biotechnologies.

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Publication Details

Journal
Успехи современной биологии
Published
2024-08-13
DOI
https://doi.org/10.31857/s0042132424010015
Primary Topic
Glycosylation and Glycoproteins Research
Type
article
Field-Weighted Citation Impact
0.00
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article

The Potential of Lectins and their Recognized Glycoconjugates in the Human Body

S. S. Afanasiev, Mironov AIu, S. Yu. Kombarova, В. М. Лахтин et al.
26 links
Успехи современной биологии
Glycosylation and Glycoproteins Research
article

The Potential of Lectins and their Recognized Glycoconjugates in the Human Body

S. S. Afanasiev, Mironov AIu, S. Yu. Kombarova, В. М. Лахтин, V. A. Aleshkin, М. В. Лахтин
article en

Abstract

The modern concepts of lectins and glycoconjugates binding to them, the features and patterns of their interaction, the protective role and potential in the human body are summarized. The analysis of terms, approaches to classifications of lectins is carried out. The features of natural and synthetic glycoconjugates, recognized and bound by lectins, in symbiotic relationships, in innate immunity at the reception level are emphasized. The levels of specificity of lectins are considered. There is a need to expand research on the glycoconjugate specificity of lectins and their systems, to assess the communication potential of glycoconjugates in relation to any protein combinations and systems as lectins. The participation of lectin and glycoconjugate systems in signal transmission and communication is noted. Lectins manifest themselves as basic for superstructure glycoconjugate effectors in soluble and solid cell phases in cascade directed assemblies forming the interactome network. Lectins and glycoconjugates, as inextricably co-functioning, are promising in biology, medicine and biotechnologies.

Успехи современной биологииVol. 144(1)
Gabrichevsky Institute of Epidemiology and Microbiology (RU), Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (RU)
Openalex Percentile: Top 88%
Glycosylation and Glycoproteins Research
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