The SEMA3F-NRP1/NRP2 axis is a key factor in the acquisition of invasive traits in in situ breast ductal carcinoma
Together with our patient database data, these proof-of-concept results reveal new SEMA3F-mediated mechanisms occurring in the most common preinvasive BC lesion, DCIS, and represent potent and direct activation of its transition to invasion. Moreover, and of clinical and therapeutic relevance, the effects of SEMA3F can be blocked directly through its coreceptors, thus preventing invasion and keeping DCIS lesions in the preinvasive state.
Authors
- Paloma Bragado (ORCID: https://orcid.org/0000-0002-7642-1245)
- Aleix Noguera‐Castells (ORCID: https://orcid.org/0000-0001-7436-6513)
- Gemma Fuster (ORCID: https://orcid.org/0000-0002-4501-2422)
- Neus Carbó (ORCID: https://orcid.org/0000-0001-8208-6896)
- Xieng Chen
- Jamie L. Inman (ORCID: https://orcid.org/0000-0002-6056-1219)
- Helga Bergholtz (ORCID: https://orcid.org/0000-0003-0999-1106)
- Leire Recalde‐Percaz (ORCID: https://orcid.org/0000-0002-4844-8440)
- Núria Moragas (ORCID: https://orcid.org/0009-0002-8863-3947)
- Thérese Sørlie (ORCID: https://orcid.org/0000-0002-5995-2319)
- Pere Gascón
- Mina J. Bissell (ORCID: https://orcid.org/0000-0001-5841-4423)
- Patricia Fernández‐Nogueira (ORCID: https://orcid.org/0000-0002-7246-490X)
- Pedro J. del Burgo
- Anna López‐Plana (ORCID: https://orcid.org/0000-0002-1080-7663)
Institutions
- Universitat de Vic - Universitat Central de Catalunya (ES)
- Universidad Complutense de Madrid (ES)
- Oslo University Hospital (NO)
- Lawrence Berkeley National Laboratory (US)
- Hospital Clínico San Carlos (ES)
- Josep Carreras Leukaemia Research Institute (ES)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
- Institute for Research in Biomedicine (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2024-08-13
- DOI
- https://doi.org/10.1186/s13058-024-01871-0
- Citations
- 2
- Primary Topic
- Axon Guidance and Neuronal Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- Fundación Cellex
- Ministerio de Economía y Competitividad
- Banco Bilbao Vizcaya Argentaria
- Universitat de Barcelona