M2-like tumor-associated macrophage-secreted CCL2 facilitates gallbladder cancer stemness and metastasis
The interaction between M2-like TAMs and GBC cells is mediated by the chemokine CCL2, which activates the MEK/ERK/ELK1/SNAIL pathway in GBC cells, promoting EMT, stemness, and metastasis. A combination of a CCR2 inhibitor and gemcitabine effectively suppressed the growth of subcutaneous tumors. Consequently, our study identified promising therapeutic targets and strategies for treating GBC.
Authors
- Maotuan Huang
- Yanling Chen (ORCID: https://orcid.org/0000-0003-4407-4880)
- Ming‐Yuan Chen (ORCID: https://orcid.org/0000-0003-4793-0902)
- Feifei She (ORCID: https://orcid.org/0000-0001-6947-2426)
- Lingju Hong
- Weihong Chen
- Nanhong Tang
- Xinyue Yang (ORCID: https://orcid.org/0000-0002-7277-7252)
- Abudukeremu Xiahenazi
Institutions
- Fujian Medical University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2024-08-13
- DOI
- https://doi.org/10.1186/s40164-024-00550-2
- Citations
- 24
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 6.78