A Refined Population Pharmacokinetic Model–Based Guideline for Individualized PEGasparaginase Dosing in Pediatric Acute Lymphoblastic Leukemia
With the new dosing guideline, fewer dose-reduction steps are necessary to reach and remain within the target. The high adherence rate emphasized its simplicity and practicality, confirming that it can be easily integrated into clinical practice.
Authors
- Inge M. van der Sluis (ORCID: https://orcid.org/0000-0002-5822-7668)
- Leiah J. Brigitha (ORCID: https://orcid.org/0000-0003-2816-2610)
- Karen Zaky
- Rob Pieters
Institutions
- Princess Máxima Center (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2024-08-13
- DOI
- https://doi.org/10.1097/ftd.0000000000001252
- Citations
- 2
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 1.09