NaIO4/NH2OH-mediated Efficient Synthesis of Phosphoroamidates from Anilines and Triethyl Phosphite
Abstract A simple, efficient, and metal-free method was developed for the synthesis of phosphoroamidates. In essence, a mixture of sodium periodate (NaIO4) and hydroxylamine (NH2OH⸱HCl) was used in stoichiometric amounts to execute the phosphoramidation reaction of aromatic amines and triethyl phosphites at room temperature, in open air. This method offers a practical synthesis route to afford a diverse range of phosphoroamidates via the construction of P − N bonds, with excellent functional group compatibility and good yields under mild conditions.
Authors
- E. V. Venkat Shivaji Ramarao (ORCID: https://orcid.org/0000-0002-1548-8032)
- Rana Chatterjee (ORCID: https://orcid.org/0000-0003-4247-2084)
- V. Dhayalan (ORCID: https://orcid.org/0000-0003-4548-2894)
- Rambabu Dandela (ORCID: https://orcid.org/0000-0002-2764-782X)
- Jayshree Nandkumar Solanke (ORCID: https://orcid.org/0009-0007-6040-0515)
- Savita Gat
Institutions
- Institute of Chemical Technology (IN)
- University of Hyderabad (IN)
- Institute of Life Sciences (IN)
- National Institute of Technology, Puducherry
- Oil India (India) (IN)
- Indian Institute of Technology Bhubaneswar (IN)
Publication Details
- Journal
- Sustainability & Circularity NOW
- Published
- 2024-08-13
- DOI
- https://doi.org/10.1055/a-2386-5537
- Primary Topic
- Chemical Synthesis and Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Engineering Research Board