AMELIORATION OF ALUMINIUM FLUORIDE TOXICITY BY ALOE VERA ON BLOOD PARAMETERS IN MALE ALBINO RATS

It is suspected that drinking water containing fluoride (F) and aluminum (Al) results in negative health effects in the human and animals. Its toxic effect in the especially on blood, brain, liver, and kidney. In this investigation, the effect of AlF3 blood disease was noted. Albino rats were treated either with WHO recommended or slightly higher F and Al levels in drinking water. Treatment solutions contained 0.05–10.0 mg/L of F, and 0.08–10.0 mg/L of Al, and the treatment period was 45 days. Aloe vera gel (Aloes) is a member of the family Liliaceae that is used as herbal or medicine in many cultures for different purposes. The present study was designed to observe the role of Aloe vera gel on blood parameters in rats. The present study was designed to assess the ameliorative effect of Aloe vera gel on aluminium fluoride induced toxic changes in blood parameters of albino rats. The present study was carried out 60 male albino rats that were randomly divided into three groups consisting of 20 rats in each group. Aluminium fluoride was gavages per orally using distill water as vehicle 200mg/kg b. w. to group II and Aloe vera 300mg/kg b. w. in distilled water was given along with AlF3 to group III for 45 days to study of ameliorative effects group I is a control group. Ten rats from each group were sacrificed at sixteenth and forty sixth day night interval. Entire changes were observed in blood cells. The haematological parameters TEC, Hb. Conc., MCV significant decrease treated with AlF3, and TLC, PVC, MCH, MCHC and ESR significant increase after 45 days treated with AlF3 compared with the control group. Treated with AlF3 along with Aloe vera gel all parameters significant increased compared with the control group. These results showed that Aloe vera gel have haematoprotective effects in experimently induced AlF3 rats. This study concluded that Aloe vera gel has haematoprotective effect against aluminium fluoride induced haematotoxicity.