Lupiwighteone as an Antitumor Agent Reverses Multidrug Resistance in K562/ADR Cells by Regulating Cellular Prion Protein-Oct4 Axis
In addition, when Lup was combined with adriamycin, Lup decreased the IC<sub>50</sub> of K562/ADR cells; moreover, Lup can downregulate the expression of drug-resistant proteins, suggesting that Lup can reverse drug resistance. Further studies have shown that Lup can downregulate the expression of PrP<sup>C</sup>-PI3K-Akt axis proteins and PrP<sup>C</sup>-Oct4 axis proteins. This study demonstrated that Lup has the potential to inhibit the proliferation of K562/ADR cells by targeting PrP<sup>C</sup>, and further study of the signaling pathway associated with PrP<sup>C</sup> may provide the experimental basis for the treatment of drug-resistant leukemia.
Authors
- Pengcheng Ding (ORCID: https://orcid.org/0009-0003-1856-9510)
- Shuxia Mao
- Yanan Zhang (ORCID: https://orcid.org/0000-0001-6315-0936)
- Kun Hu (ORCID: https://orcid.org/0000-0003-4420-2467)
- Xin Jin (ORCID: https://orcid.org/0000-0001-9121-4597)
- Jinling Zhang (ORCID: https://orcid.org/0000-0003-2055-4601)
- Shaojun Wu
- Xinyuan Wu (ORCID: https://orcid.org/0009-0002-9319-9153)
- Jie Ren (ORCID: https://orcid.org/0000-0002-7967-6243)
Institutions
- Changzhou University (CN)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2024-08-12
- DOI
- https://doi.org/10.2174/0118715206316284240807100226
- Citations
- 3
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.40