Efficacy Versus Effectiveness: The HORIZON‐Pivotal Fracture Trial and Its Emulation in Claims Data
Real-world emulation of the HORIZON-PFT found that zoledronic acid reduced hip fractures risk over an 18-month follow-up period. Limited adherence in clinical practice diminished the magnitude of its preventive effect and precluded long-term estimation of effectiveness in this setting.
Authors
- Sebastian Schneeweiß (ORCID: https://orcid.org/0000-0003-2575-467X)
- Elvira D’Andrea (ORCID: https://orcid.org/0000-0002-5263-3964)
- Robert J. Glynn (ORCID: https://orcid.org/0000-0002-0697-8996)
- Shirley Wang (ORCID: https://orcid.org/0000-0001-7761-7090)
- Jessica M. Franklin (ORCID: https://orcid.org/0000-0002-8941-4116)
- Su Been Lee (ORCID: https://orcid.org/0000-0002-3437-097X)
- Seoyoung C. Kim (ORCID: https://orcid.org/0000-0002-2517-3579)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1002/art.42968
- Citations
- 7
- Primary Topic
- Shoulder Injury and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.01