Ligand‐Enabled Gold‐Catalyzed Cyanation of Organohalides
Herein, we disclose the first report on gold-catalyzed C(sp<sup>2</sup>)-CN cross-coupling reaction by employing a ligand-enabled Au(I)/Au(III) redox catalysis. This transformation utilizes acetone cyanohydrin as a nucleophilic cyanide source to convert simple aryl and alkenyl iodides into the corresponding nitriles. Combined experimental and computational studies highlighted the crucial role of cationic silver salts in activating the stable (P,N)-AuCN complex towards the oxidative addition of aryl iodides to subsequently generate key aryl-Au(III) cyanide complexes.
Authors
- Nitin T. Patil (ORCID: https://orcid.org/0000-0002-8372-2759)
- Anil Kumar (ORCID: https://orcid.org/0000-0003-4937-0363)
- Manoj V. Mane (ORCID: https://orcid.org/0000-0001-8236-3638)
- Nandita Bhattacharya (ORCID: https://orcid.org/0009-0009-3481-9034)
Institutions
- Jain University (IN)
- Indian Institute of Science Education and Research, Bhopal (IN)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1002/anie.202412682
- Citations
- 19
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 4.75