Multi-omics landscapes reveal heterogeneity in long COVID patients characterized with enhanced neutrophil activity
The transcriptomic and proteomic profiling revealed heterogeneity among long COVID patients. We discovered a subgroup of long COVID population characterized by neutrophil activation, which might associate with the development of psychiatric symptoms and indicate a higher inflammatory state. Meanwhile, a cluster of 5 genes was manually curated as the most potent discriminators of NU-LC from long COVID population. This study can serve as a foundational exploration of the heterogeneity in the pathogenesis of long COVID and assist in therapeutic targeting and detailed epidemiological investigation of long COVID.
Authors
- H. C. Zhang (ORCID: https://orcid.org/0000-0001-9826-1759)
- Jingwen Ai (ORCID: https://orcid.org/0000-0002-5152-1557)
- Jingxin Guo (ORCID: https://orcid.org/0000-0002-3099-7900)
- Guanmin Yuan
- Kun Zhu (ORCID: https://orcid.org/0000-0001-7652-7640)
- Wenhong Zhang (ORCID: https://orcid.org/0000-0002-9165-3212)
- Pengfei Wang (ORCID: https://orcid.org/0000-0002-9081-3683)
- Ke Lin (ORCID: https://orcid.org/0000-0003-3675-9054)
- Quanlin Xue
- Yuhan Sun (ORCID: https://orcid.org/0000-0001-8371-8285)
- Feng Zhu (ORCID: https://orcid.org/0000-0002-4330-0789)
- Jian‐Peng Cai
- Gangqiang Sun
- Xun Wang (ORCID: https://orcid.org/0000-0001-9545-7350)
- Sen Wang (ORCID: https://orcid.org/0009-0005-2988-4510)
Institutions
- Jiangnan University (CN)
- Fudan University (CN)
- Shanghai Public Health Clinical Center (CN)
- Pudong Medical Center (CN)
- Wuxi People's Hospital (CN)
- Huashan Hospital (CN)
- Institute of Infection and Immunity (CA)
- State Key Laboratory of Genetic Engineering
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1186/s12967-024-05560-6
- Citations
- 11
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- National Key Research and Development Program of China