A Low Expression of NRF2 Enhances Oxidative Stress and Autophagy in Myofibroblasts, Promoting Progression of Chronic Obstructive Pulmonary Disease
We identified a cell myofibroblast cluster closely associated with COPD progression using the scRNA-seq analysis. The downregulated NFR2, as a key risk factor, mediated myofibroblast death by activating the oxidative stress and autophagy pathway for COPD progression.
Authors
- Wentao Cai (ORCID: https://orcid.org/0000-0002-5639-1755)
- Chunrong Zhong
- Pin Guan (ORCID: https://orcid.org/0000-0001-7767-4722)
- Xin Zhai
- Jinchan Wu
- Fan Jiang
Institutions
- Hainan General Hospital (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2024-08-12
- DOI
- https://doi.org/10.2174/0109298673326250240806051127
- Citations
- 6
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.41