Proteomic analyses reveal plasma EFEMP1 and CXCL12 as biomarkers and determinants of neurodegeneration

Plasma proteomic signatures are associated with unique patterns of brain atrophy. Brain atrophy-related proteins predict clinically relevant outcomes across cohorts. Genetic variation underlying plasma EFEMP1 and CXCL12 influences brain structure. EFEMP1 and CXCL12 may be important molecular drivers of neurodegeneration.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-08-11
DOI
https://doi.org/10.1002/alz.14142
Citations
13
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
4.25

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article

Proteomic analyses reveal plasma EFEMP1 and CXCL12 as biomarkers and determinants of neurodegeneration

Susan M. Resnick, Yuhan Cui, Timothy J. Hohman, Jingsha Chen et al.
13 citations
Alzheimer s & Dementia
Alzheimer's disease research and treatments
4.25
article

Proteomic analyses reveal plasma EFEMP1 and CXCL12 as biomarkers and determinants of neurodegeneration

Susan M. Resnick, Yuhan Cui, Timothy J. Hohman, Jingsha Chen, Christos A. Davatzikos, Heather E. Dark, Guray Erus, Michael R. Duggan, Abhay Moghekar, Alexandria Lewis, Keenan A. Walker, Junhao Wen, Zhijian Yang, Josef Coresh
article en
13 citations

Abstract

Plasma proteomic signatures are associated with unique patterns of brain atrophy. Brain atrophy-related proteins predict clinically relevant outcomes across cohorts. Genetic variation underlying plasma EFEMP1 and CXCL12 influences brain structure. EFEMP1 and CXCL12 may be important molecular drivers of neurodegeneration.

Alzheimer s & DementiaVol. 20(9)
University of Southern California (US), National Institutes of Health (US), Intel (United States) (US), Johns Hopkins University (US), Johns Hopkins Medicine (US), National Institute on Aging (US), New York University (US), University of Pennsylvania (US), Vanderbilt University Medical Center (US)
National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Neurological Disorders and Stroke
Openalex Percentile: Top 5%
Alzheimer's disease research and treatments
4.25
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