Proteomic analyses reveal plasma EFEMP1 and CXCL12 as biomarkers and determinants of neurodegeneration
Plasma proteomic signatures are associated with unique patterns of brain atrophy. Brain atrophy-related proteins predict clinically relevant outcomes across cohorts. Genetic variation underlying plasma EFEMP1 and CXCL12 influences brain structure. EFEMP1 and CXCL12 may be important molecular drivers of neurodegeneration.
Authors
- Susan M. Resnick (ORCID: https://orcid.org/0000-0003-1115-7145)
- Yuhan Cui (ORCID: https://orcid.org/0000-0002-0017-0056)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Jingsha Chen
- Christos A. Davatzikos (ORCID: https://orcid.org/0000-0002-1025-8561)
- Heather E. Dark (ORCID: https://orcid.org/0000-0001-7194-3637)
- Guray Erus
- Michael R. Duggan (ORCID: https://orcid.org/0000-0002-1029-4423)
- Abhay Moghekar (ORCID: https://orcid.org/0000-0001-9464-1551)
- Alexandria Lewis (ORCID: https://orcid.org/0000-0002-3812-8080)
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Junhao Wen (ORCID: https://orcid.org/0000-0003-2077-3070)
- Zhijian Yang (ORCID: https://orcid.org/0000-0002-7863-827X)
- Josef Coresh (ORCID: https://orcid.org/0000-0002-4598-0669)
Institutions
- University of Southern California (US)
- National Institutes of Health (US)
- Intel (United States) (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- National Institute on Aging (US)
- New York University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-08-11
- DOI
- https://doi.org/10.1002/alz.14142
- Citations
- 13
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.25
Funders
- National Institutes of Health
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Institute on Deafness and Other Communication Disorders
- National Institute of Neurological Disorders and Stroke