The MIND diet, brain transcriptomic alterations, and dementia
Why healthy dietary patterns are associated with lower dementia risk are unknown. We integrated dietary, brain transcriptomic, and cognitive data in older adults. Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet intake is correlated with a specific brain transcriptomic profile. This brain transcriptomic profile score is associated with better cognitive health. More data are needed to elucidate the causality and functionality of identified genes.
Authors
- Shinya Tasaki (ORCID: https://orcid.org/0000-0003-3656-7394)
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Ana W. Capuano (ORCID: https://orcid.org/0000-0002-3505-344X)
- Zoe Arvanitakis (ORCID: https://orcid.org/0000-0001-7477-8884)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0002-9482-1752)
- Liming Liang (ORCID: https://orcid.org/0000-0001-8261-3174)
- Kátia de Paiva Lopes (ORCID: https://orcid.org/0000-0002-0240-0126)
- Frank B. Hu (ORCID: https://orcid.org/0000-0002-8233-6274)
- Puja Agarwal
- Francine Grodstein (ORCID: https://orcid.org/0000-0002-2699-7051)
- Jun Li (ORCID: https://orcid.org/0000-0003-3519-8638)
- Philip L. De Jager
- Yanling Wang (ORCID: https://orcid.org/0009-0003-0061-9946)
Institutions
- Brigham and Women's Hospital (US)
- Rush University Medical Center (US)
- Harvard University (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-08-11
- DOI
- https://doi.org/10.1002/alz.14062
- Citations
- 17
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- National Institute on Aging
- National Institute of Diabetes and Digestive and Kidney Diseases