<i>APOE</i> ε4–associated downregulation of the IL‐7/IL‐7R pathway in effector memory T cells: Implications for Alzheimer's disease
The apolipoprotein E (APOE) ε4 allele decreases plasma interleukin (IL)-7 and aggravates hippocampal atrophy in Alzheimer's disease. Plasma IL-7 level is negatively associated with the degree of hippocampal atrophy. The expression of IL-7R signaling decreased in peripheral blood mononuclear cells of APOE ε4 carriers Dysregulation of the IL-7/IL-7R signal pathways enriches T cells.
Authors
- Changhao Lu (ORCID: https://orcid.org/0009-0000-1419-3868)
- Hailiang Tang (ORCID: https://orcid.org/0000-0003-1852-3128)
- Zhijie Lu (ORCID: https://orcid.org/0000-0002-0561-0591)
- Renhua Wu (ORCID: https://orcid.org/0000-0001-9803-2825)
- Jitian Guan (ORCID: https://orcid.org/0000-0002-8910-7052)
- Nan Kong (ORCID: https://orcid.org/0000-0002-4047-3414)
- An‐Xiang Dai
- Ya‐Qi Wen
- Ting Hou
- Naili Wei (ORCID: https://orcid.org/0000-0003-3573-199X)
- Hao‐Xin Liu
- Xin Zeng
- Hui Pan (ORCID: https://orcid.org/0000-0001-6873-5749)
- Cheng Yan (ORCID: https://orcid.org/0000-0002-4909-439X)
- Yingjie Zhang (ORCID: https://orcid.org/0000-0002-5936-1025)
- Kai Huang (ORCID: https://orcid.org/0000-0003-0359-7810)
- Shengliang Xu
- Yan Lin (ORCID: https://orcid.org/0000-0002-8284-9029)
- Yue Qi (ORCID: https://orcid.org/0000-0001-7670-8599)
- Xinyi Cai (ORCID: https://orcid.org/0000-0002-4444-4231)
- Xiaoyu Ji (ORCID: https://orcid.org/0009-0005-6004-6419)
- Wenbin Zheng (ORCID: https://orcid.org/0000-0002-1587-5067)
- W Ma (ORCID: https://orcid.org/0009-0001-0593-1299)
- Yi‐Xuan Hao
- Jie Wu (ORCID: https://orcid.org/0000-0002-9877-1764)
Institutions
- Fudan University (CN)
- Shantou University (CN)
- Second Hospital of Shandong University (CN)
- Yue Bei People's Hospital (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Shantou University Medical College (CN)
- Second Affiliated Hospital of Shantou University Medical College (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-08-11
- DOI
- https://doi.org/10.1002/alz.14173
- Citations
- 15
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.71
Funders
- Li Ka Shing Foundation
- Shantou University
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Shantou University Medical College
- Basic and Applied Basic Research Foundation of Guangdong Province