Integrated molecular profiling of RAS, BRAF mutations, and mismatch repair status in advanced colorectal carcinoma: insights from gender and tumor laterality
Deficiency in the MMR system is associated with the presence of the <i>BRAF</i> V600E mutation, tumors located in the right colon, and the female sex. In our case series, more than 60% of patients had at least one mutation in <i>KRAS</i>, <i>NRAS</i>, or <i>BRAF</i>. The presence of mutations in these genes is closely related to CRC prognosis and helps define the best therapeutic approach in patients with metastatic CRC.
Authors
- Fernanda de Paris (ORCID: https://orcid.org/0000-0003-2563-9487)
- Pedro Guilherme Schaefer (ORCID: https://orcid.org/0000-0003-2792-6586)
- Emily Ferreira Salles Pilar (ORCID: https://orcid.org/0000-0003-3417-3586)
- Gabriela Remonatto (ORCID: https://orcid.org/0000-0001-6150-9407)
- Lúcia Maria Kliemann (ORCID: https://orcid.org/0000-0001-7249-7800)
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
Publication Details
- Journal
- Journal of Gastrointestinal Oncology
- Published
- 2024-08-01
- DOI
- https://doi.org/10.21037/jgo-23-1017
- Citations
- 4
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- Hospital de Clínicas de Porto Alegre
- Fundação Instituto de Pesquisas Econômicas