Systematic metabolic profiling of mice with caerulein-induced acute pancreatitis
Our study highlights the utility of metabolomics in identifying potential biomarkers for early diagnosis of AP and elucidating associated metabolic pathways. 3-HBA, BCAAs, phenylalanine and L-lysine emerge as promising biomarkers for further clinical validation. These findings contribute to a better understanding of AP pathophysiology and underscore the potential of metabolomics in precision medicine approaches for AP management.
Authors
- Pei Jiang (ORCID: https://orcid.org/0000-0002-8360-7427)
- Shiyuan Zhao
- Benhui Liang (ORCID: https://orcid.org/0000-0002-9345-4161)
- Yazhou Zhang (ORCID: https://orcid.org/0000-0002-3387-8093)
- Shanshan Wei (ORCID: https://orcid.org/0000-0003-4185-0346)
- Linqiang Gong
- Shuhui Li (ORCID: https://orcid.org/0009-0006-0040-6504)
- Hui Yang (ORCID: https://orcid.org/0009-0001-6253-357X)
Institutions
- Central South University (CN)
- Shandong Provincial Hospital (CN)
- Jining First People's Hospital (CN)
- Tengzhou Central People's Hospital (CN)
- Xiangya Hospital Central South University (CN)
- Shandong First Medical University (CN)
- Jining Medical University (CN)
Publication Details
- Journal
- Translational Gastroenterology and Hepatology
- Published
- 2024-08-12
- DOI
- https://doi.org/10.21037/tgh-24-14
- Citations
- 1
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- China International Medical Foundation