NOVA2 regulates the properties of liver cancer stem cells and lenvatinib resistance in hepatocellular carcinoma via the Wnt pathway
NOVA2 is involved in the process of liver CSC self-renewal and carcinogenesis. In addition, NOVA2 expression may help identify patients with a higher chance of benefiting from lenvatinib treatment and can be a promising therapeutic target for HCC.
Authors
- Zheng Shi (ORCID: https://orcid.org/0000-0001-8282-3913)
- Francisco Tustumi (ORCID: https://orcid.org/0000-0001-6695-0496)
- Christine Pocha (ORCID: https://orcid.org/0000-0002-2906-1144)
- Diamantis I. Tsilimigras (ORCID: https://orcid.org/0000-0002-3676-9263)
- Tiago Biachi De Castria (ORCID: https://orcid.org/0000-0001-6832-2485)
- Chao-Qun Wang
- Lü Jin (ORCID: https://orcid.org/0000-0001-7933-0309)
- Jennifer D. Wu (ORCID: https://orcid.org/0000-0002-8925-268X)
- Jingyun Song
- Tao Tao
- Jing-Zhu Cao
- Zhihong Wang (ORCID: https://orcid.org/0009-0000-1502-5487)
Institutions
- Second Military Medical University (CN)
- Universidade de São Paulo (BR)
- University of South Florida (US)
- The Ohio State University Wexner Medical Center (US)
- Moffitt Cancer Center (US)
- NYU Langone Health (US)
- Changhai Hospital (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
Publication Details
- Journal
- Journal of Gastrointestinal Oncology
- Published
- 2024-08-01
- DOI
- https://doi.org/10.21037/jgo-24-145
- Citations
- 6
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Massachusetts Department of Agricultural Resources
- George Washington University