Clinical protocol phase II study of tumor infiltrating lymphocytes in advanced tumors with alterations in the SWI/SNF complex: the TILTS study
The SWI/SNF complex is a chromatin remodeling complex comprised by several proteins such as SMARCA4 or SMARCB1. Mutations in its components can lead to the development of aggressive rhabdoid tumors such as epithelioid sarcoma, malignant rhabdoid tumor or small cell carcinoma of the ovary hypercalcemic type, among others. These malignancies tend to affect young patients and their prognosis is poor given the lack of effective treatments. Characteristically, these tumors are highly infiltrated by TILs, suggesting that some lymphocytes are recognizing tumor antigens. The use of those TILs as a therapeutic strategy is a promising approach worth exploring. Here, we report the clinical protocol of the TILTS study, a Phase II clinical trial assessing personalized adoptive cell therapy with TILs in patients affected by these tumor types.<b>Clinical Trial Registration</b>: 2023-504632-17-00 (www.clinicaltrialsregister.eu) (ClinicalTrials.gov).
Authors
- Jesús García-Donás (ORCID: https://orcid.org/0000-0001-7731-3601)
- Alena Gros (ORCID: https://orcid.org/0000-0002-1207-1880)
- Silvia Martin Lluesma (ORCID: https://orcid.org/0000-0001-7491-1876)
- Júlia Lostes
- J.J. Soto Castillo (ORCID: https://orcid.org/0000-0001-9630-4233)
- Carles Codony (ORCID: https://orcid.org/0000-0001-8928-2312)
- Josep M. Piulats (ORCID: https://orcid.org/0000-0002-3606-1724)
- Vladimir Galvao (ORCID: https://orcid.org/0009-0007-8139-8215)
- Cristina Prat‐Vidal (ORCID: https://orcid.org/0000-0002-5621-1101)
- Susana Muñoz (ORCID: https://orcid.org/0000-0003-0543-8100)
- Alberto Mussetti (ORCID: https://orcid.org/0000-0002-4088-036X)
- Xavier García del Muro (ORCID: https://orcid.org/0000-0001-5571-2847)
- Juan Martín-Liberal (ORCID: https://orcid.org/0000-0003-2552-5172)
- Elena Garralda (ORCID: https://orcid.org/0000-0002-4412-7842)
- Marta Rotxés
- Rafael Moreno
- Anna Sureda (ORCID: https://orcid.org/0000-0002-1238-6970)
- Ramón Alemany (ORCID: https://orcid.org/0000-0001-8660-550X)
- Jara Palomero (ORCID: https://orcid.org/0000-0002-2092-2526)
- Ainhoa Muñoz
Institutions
- Institut Català d'Ornitologia (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Institut Català d'Oncologia (ES)
- HM Hospitales (ES)
- Banc de Sang i Teixits (ES)
- Vall d'Hebron Institute of Oncology (ES)
Publication Details
- Journal
- Future Oncology
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1080/14796694.2024.2385287
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundación BBVA
- Centres de Recerca de Catalunya
- Instituto de Salud Carlos III