Leptin bioavailability and markers of brain atrophy and vascular injury in the middle age

Higher leptin bioavailability was related to better preservation of white matter microstructure. Higher leptin bioavailability during midlife might confer protection against dementia. Potential benefits might be even stronger for individuals with visceral obesity. DTI measures might be sensitive surrogate markers of subclinical neuropathology.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-08-12
DOI
https://doi.org/10.1002/alz.13879
Citations
10
Primary Topic
Regulation of Appetite and Obesity
Type
article
Field-Weighted Citation Impact
2.74

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article

Leptin bioavailability and markers of brain atrophy and vascular injury in the middle age

Charles DeCarli, Ramachandran Srini Vasan, Alison M. Luckey, Sudha S. Seshadri et al.
10 citations
Alzheimer s & Dementia
Regulation of Appetite and Obesity
2.74
article

Leptin bioavailability and markers of brain atrophy and vascular injury in the middle age

Charles DeCarli, Ramachandran Srini Vasan, Alison M. Luckey, Sudha S. Seshadri, Mohamad Habes, Asra Aslam, Tiffany F. Kautz, Pauline Maillard, Alexa S. Beiser, Meghan I. Short, Hector Trevino, Sokratis Charisis, Nikolaos Scarmeas, Eric L. Shipp, Angel Gabriel Velarde Dediós, Jazmyn A Muhammad, Claudia Liliana Satizábal, Rebecca Bernal, Jayandra J. Himali, Julia Mathews
article en
10 citations

Abstract

Higher leptin bioavailability was related to better preservation of white matter microstructure. Higher leptin bioavailability during midlife might confer protection against dementia. Potential benefits might be even stronger for individuals with visceral obesity. DTI measures might be sensitive surrogate markers of subclinical neuropathology.

Alzheimer s & DementiaVol. 20(9)
Boston University (US), Tufts Medical Center (US), The University of Texas at San Antonio Health Science Center (US), National and Kapodistrian University of Athens (GR), Institute for Neurodegenerative Disorders (US), Framingham Heart Study (US), Columbia University (US), University of California, Davis (US)
School of Medicine, Boston University, National Institutes of Health, National Institute on Aging, National Institute of Neurological Disorders and Stroke
Openalex Percentile: Top 10%
Regulation of Appetite and Obesity
2.74
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