Leptin bioavailability and markers of brain atrophy and vascular injury in the middle age
Higher leptin bioavailability was related to better preservation of white matter microstructure. Higher leptin bioavailability during midlife might confer protection against dementia. Potential benefits might be even stronger for individuals with visceral obesity. DTI measures might be sensitive surrogate markers of subclinical neuropathology.
Authors
- Charles DeCarli
- Ramachandran Srini Vasan (ORCID: https://orcid.org/0000-0001-7357-5970)
- Alison M. Luckey (ORCID: https://orcid.org/0000-0002-1294-4696)
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Mohamad Habes (ORCID: https://orcid.org/0000-0001-9447-5805)
- Asra Aslam (ORCID: https://orcid.org/0000-0002-2654-4255)
- Tiffany F. Kautz (ORCID: https://orcid.org/0000-0001-7680-4708)
- Pauline Maillard (ORCID: https://orcid.org/0000-0003-3516-6345)
- Alexa S. Beiser (ORCID: https://orcid.org/0000-0001-8551-7778)
- Meghan I. Short (ORCID: https://orcid.org/0000-0002-7849-0180)
- Hector Trevino (ORCID: https://orcid.org/0009-0008-8067-3681)
- Sokratis Charisis (ORCID: https://orcid.org/0000-0001-6578-393X)
- Nikolaos Scarmeas (ORCID: https://orcid.org/0000-0001-6453-8908)
- Eric L. Shipp
- Angel Gabriel Velarde Dediós
- Jazmyn A Muhammad
- Claudia Liliana Satizábal (ORCID: https://orcid.org/0000-0002-1115-4430)
- Rebecca Bernal
- Jayandra J. Himali
- Julia Mathews
Institutions
- Boston University (US)
- Tufts Medical Center (US)
- The University of Texas at San Antonio Health Science Center (US)
- National and Kapodistrian University of Athens (GR)
- Institute for Neurodegenerative Disorders (US)
- Framingham Heart Study (US)
- Columbia University (US)
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1002/alz.13879
- Citations
- 10
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 2.74
Funders
- School of Medicine, Boston University
- National Institutes of Health
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke