Spatial and temporal patterns of cortical mean diffusivity in Alzheimer's disease and suspected non‐Alzheimer's disease pathophysiology
Cortical mean diffusivity (cMD) was more sensitive to detecting structural changes than macrostructural factors. Tau-related cMD increases partially mediated amyloid beta-related cognitive decline in Alzheimer's disease (AD). White matter hyperintensity-related higher cMD mainly explained the age-related cognitive decline in suspected non-Alzheimer's pathophysiology (SNAP). cMD may assist in tracking earlier neurodegenerative signs in AD and SNAP.
Authors
- Tengfei Guo (ORCID: https://orcid.org/0000-0003-2982-0865)
- Yalin Zhu
- Ting Ma (ORCID: https://orcid.org/0000-0002-1100-3472)
- Yue Cai (ORCID: https://orcid.org/0000-0002-3711-5325)
- Anqi Li (ORCID: https://orcid.org/0000-0003-1409-1858)
- Pan Sun (ORCID: https://orcid.org/0000-0002-7135-2631)
- Shaohua Ma (ORCID: https://orcid.org/0000-0001-6649-171X)
- Zhengbo He
- Jie Yang (ORCID: https://orcid.org/0000-0002-6833-2680)
Institutions
- Shenzhen Institute of Information Technology (CN)
- Peking University (CN)
- Harbin Institute of Technology (CN)
- Shenzhen Bay Laboratory (CN)
- Tsinghua–Berkeley Shenzhen Institute (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1002/alz.14176
- Citations
- 23
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 7.88
Funders
- National Natural Science Foundation of China
- Shenzhen Bay Laboratory