Transcriptomic Profile of Lin−Sca1+c-kit (LSK) cells in db/db mice with long-standing diabetes
Our findings highlight that chronic diabetes adversely alters HSCs' homeostasis at the transcriptional level, thus potentially contributing to the inflammatory phenotype of HSCs under long-term diabetes. We also believe that identifying HSCs-based biomarkers in miRNAs or mRNAs could serve as diagnostic markers and potential therapeutic targets for diabetes and associated vascular complications.
Authors
- Qianyi Luo (ORCID: https://orcid.org/0000-0002-7511-3072)
- Ashay D. Bhatwadekar (ORCID: https://orcid.org/0000-0003-0190-0505)
- Neha Mahajan
- Surabhi Abhyankar
Institutions
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1186/s12864-024-10679-3
- Citations
- 3
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- National Eye Institute