High expression of L-GILZ transcript variant 1 (GILZ TV 1) is associated with increased 30-day sepsis mortality, and a high expression ratio possibly contraindicates hydrocortisone administration
High expression of GILZ TV 1 is associated with a higher 30-day sepsis mortality rate. Moreover, a high expression ratio of GILZ TV 1 relative to all GILZ transcript variants is a parameter for identifying patient subgroups in which hydrocortisone may be contraindicated.
Authors
- Birte Dyck (ORCID: https://orcid.org/0000-0002-1013-0015)
- Britta Marko
- Björn Ellger
- Ulrich Limper (ORCID: https://orcid.org/0000-0001-9927-4180)
- Stefan Ehrentraut (ORCID: https://orcid.org/0000-0001-5747-6737)
- Dietrich Henzler (ORCID: https://orcid.org/0000-0001-5511-6885)
- Matthias Unterberg (ORCID: https://orcid.org/0000-0002-1500-1984)
- Tim Rahmel (ORCID: https://orcid.org/0000-0002-7039-6288)
- Lars Palmowski
- Lars Bergmann (ORCID: https://orcid.org/0000-0002-8603-8549)
- Elke Schwier (ORCID: https://orcid.org/0000-0002-9279-2986)
- Björn Koos (ORCID: https://orcid.org/0000-0002-0544-4124)
- Katharina Rump (ORCID: https://orcid.org/0000-0003-2220-519X)
- Michael Adamzik (ORCID: https://orcid.org/0000-0002-7188-4873)
- Patrick Thon
- Hartmuth Nowak (ORCID: https://orcid.org/0000-0002-6509-1463)
- Dominik Ziehe
- Stefan Rusev (ORCID: https://orcid.org/0009-0006-8460-4224)
Institutions
- Witten/Herdecke University (DE)
- University Hospital Bonn (DE)
- Klinikum Westfalen (Germany) (DE)
- Universitätsklinikum Knappschaftskrankenhaus Bochum (DE)
- Herford Hospital (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Critical Care
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1186/s13054-024-05056-1
- Citations
- 2
- Primary Topic
- Adrenal Hormones and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- Ruhr-Universität Bochum