Multi-regulatory potency of USP1 on inflammasome components promotes pyroptosis in thyroid follicular cells and contributes to the progression of Hashimoto's thyroiditis
Our study highlights a regulatory mechanism of USP1 on inflammasome activation and pyroptosis in TFCs during HT pathogenesis. These findings expand our understanding of HT and suggest that inhibiting USP1 may be a potential treatment strategy for managing HT.
Authors
- Wenkai Ni (ORCID: https://orcid.org/0000-0001-6056-1924)
- Xuying Zhao (ORCID: https://orcid.org/0000-0002-7695-5829)
- Yunjuan Gu (ORCID: https://orcid.org/0000-0003-1887-9992)
- Wen Jie Zheng (ORCID: https://orcid.org/0000-0002-1768-4432)
- Zhifeng Gu (ORCID: https://orcid.org/0000-0002-3275-0733)
- Wenyu Ni
- Chunfeng Sun
Institutions
- Dalian Medical University (CN)
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1186/s10020-024-00885-w
- Citations
- 14
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.27
Funders
- National Natural Science Foundation of China
- Science and Technology Project of Nantong City