Immune signature in vaccinated versus non-vaccinated aged people with COVID-19 pneumonia
Administration of 3 vaccination doses reduces the severe symptomatology in aged and elderly. Vaccination showed a strong association with anti-SARS-CoV-2 humoral response and an expansion of Th2 T-cells populations, independently of age. Delta variants and number of vaccine doses affected the magnitude of the humoral response against the original SARS-CoV-2 and emerging variants. A systematic surveillance of the emerging variants is paramount to define future vaccination strategies.
Authors
- Lucia Lopalco
- Chiara Piubelli (ORCID: https://orcid.org/0000-0002-5739-3795)
- Alessandra Ruggiero (ORCID: https://orcid.org/0000-0002-3336-6143)
- Nigel James Temperton (ORCID: https://orcid.org/0000-0002-7978-3815)
- Uberti-Foppa Caterina
- Di Serio Mariaclelia Stefania
- Fantoni Tobia
- Cugnata Federica
- Brombin Chiara
- Rizzi Eleonora
- C. SARA
- M. Martin
- Matucci Andrea
- Pastori Claudia
- Tais Stefano
- Gianesini Natasha
Institutions
- University of Verona (IT)
- Vita-Salute San Raffaele University (IT)
- Medway School of Pharmacy (GB)
- Ospedale Sacro Cuore Don Calabria (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1186/s12967-024-05556-2
- Citations
- 3
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca