Insights into free radicals scavenging, α-Amylase inhibition, cytotoxic and antifibrotic activities unveiled by Peganum harmala extracts

P. harmala plant-fixed oil exhibits potential antioxidant properties. While the hydrophilic extract showed limited effectiveness as an anti-α-amylase agent and demonstrated notable cytotoxic effects against various tested cancer cell lines. Furthermore, this extract significantly reduces the number of LX-2 fibrotic cells. These findings emphasize the therapeutic potential of these products in managing various health disorders and warrant further investigation into their mechanisms of action and clinical applications.

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Publication Details

Journal
BMC Complementary Medicine and Therapies
Published
2024-08-12
DOI
https://doi.org/10.1186/s12906-024-04602-2
Citations
5
Primary Topic
Synthesis and bioactivity of alkaloids
Type
article
Field-Weighted Citation Impact
1.17

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article

Insights into free radicals scavenging, α-Amylase inhibition, cytotoxic and antifibrotic activities unveiled by Peganum harmala extracts

Mohammed Hawash, Shorooq Sobuh, Majid Sharifi‐Rad, Nidal Jaradat et al.
5 citations
BMC Complementary Medicine and Therapies
Synthesis and bioactivity of alkaloids
1.17
article

Insights into free radicals scavenging, α-Amylase inhibition, cytotoxic and antifibrotic activities unveiled by Peganum harmala extracts

Mohammed Hawash, Shorooq Sobuh, Majid Sharifi‐Rad, Nidal Jaradat, Linda Issa, Ali Shakhshir, Sondos Hamamrhe, Eman Al-Sheikh, Alaa Naser Ibrahim, Fatima Hussein
article en
5 citations

Abstract

P. harmala plant-fixed oil exhibits potential antioxidant properties. While the hydrophilic extract showed limited effectiveness as an anti-α-amylase agent and demonstrated notable cytotoxic effects against various tested cancer cell lines. Furthermore, this extract significantly reduces the number of LX-2 fibrotic cells. These findings emphasize the therapeutic potential of these products in managing various health disorders and warrant further investigation into their mechanisms of action and clinical applications.

BMC Complementary Medicine and TherapiesVol. 24(1)
Zabol University (IR), An-Najah National University (PS)
An-Najah National University
Zero hunger
Openalex Percentile: Top 22%
Synthesis and bioactivity of alkaloids
1.17
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