Insights into free radicals scavenging, α-Amylase inhibition, cytotoxic and antifibrotic activities unveiled by Peganum harmala extracts
P. harmala plant-fixed oil exhibits potential antioxidant properties. While the hydrophilic extract showed limited effectiveness as an anti-α-amylase agent and demonstrated notable cytotoxic effects against various tested cancer cell lines. Furthermore, this extract significantly reduces the number of LX-2 fibrotic cells. These findings emphasize the therapeutic potential of these products in managing various health disorders and warrant further investigation into their mechanisms of action and clinical applications.
Authors
- Mohammed Hawash (ORCID: https://orcid.org/0000-0001-5640-9700)
- Shorooq Sobuh
- Majid Sharifi‐Rad (ORCID: https://orcid.org/0000-0002-4319-025X)
- Nidal Jaradat (ORCID: https://orcid.org/0000-0003-2291-6821)
- Linda Issa (ORCID: https://orcid.org/0000-0001-8509-826X)
- Ali Shakhshir
- Sondos Hamamrhe
- Eman Al-Sheikh
- Alaa Naser Ibrahim
- Fatima Hussein
Institutions
- Zabol University (IR)
- An-Najah National University (PS)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1186/s12906-024-04602-2
- Citations
- 5
- Primary Topic
- Synthesis and bioactivity of alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- An-Najah National University