Enhancing mutation detection in multiple myeloma with an error-corrected ultra-sensitive NGS assay without plasma cell enrichment
This research provides valuable insights into the genetic landscape of MM and highlights the advantages of error-corrected NGS for detecting low-frequency mutations. Although the current standard method for mutation analysis is plasma cell-enriched BMAs, total BMA or ctDNA testing with error correction is a viable alternative when plasma cell enrichment is not feasible.
Authors
- Jong Rak Choi (ORCID: https://orcid.org/0000-0002-0608-2989)
- Seung‐Tae Lee (ORCID: https://orcid.org/0000-0003-1047-1415)
- Saeam Shin (ORCID: https://orcid.org/0000-0003-1501-3923)
- Jin Ju Kim (ORCID: https://orcid.org/0000-0001-9166-1848)
- Soo‐Jeong Kim (ORCID: https://orcid.org/0000-0001-8859-3573)
- Doh Yu Hwang (ORCID: https://orcid.org/0000-0002-0750-0011)
- Seoyoung Lim (ORCID: https://orcid.org/0009-0004-7944-2756)
Institutions
- Yonsei University (KR)
- Severance Hospital (KR)
- Yonsei University Health System (KR)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1186/s12935-024-03470-7
- Citations
- 3
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- National Research Foundation
- Yonsei University
- National Research Foundation of Korea
- Yonsei University College of Medicine