An Axially Chiral Quinoline-2-Carboxylic Acid-Cu Catalyst for Enantioselective Synthesis of <i>C</i><sub>2</sub>- and <i>C</i><sub>1</sub>-Symmetric BINOLs
The in situ dimeric coordination of two chiral ligands bearing quinoline-2-carboxylic acid units and substituted BINOL backbones with a copper ion generates a new chiral catalyst for oxidative homo- and cross-coupling of various 2-naphthols, enabling enantioselective synthesis of a broad range of highly useful diversely substituted <i>C</i><sub>2</sub>- and <i>C</i><sub>1</sub>-symmetric BINOLs in up to 96% yield with good to excellent enantioselectivities (up to 98:2 e.r.).
Authors
- Jun Xu (ORCID: https://orcid.org/0000-0002-0717-6194)
- Zhipeng Zhang (ORCID: https://orcid.org/0000-0003-2767-0904)
- Shouyi Cen (ORCID: https://orcid.org/0000-0002-9786-6067)
- Ahui Shen (ORCID: https://orcid.org/0000-0002-7480-1930)
- Jun Gao (ORCID: https://orcid.org/0000-0003-1145-9565)
Institutions
- East China University of Science and Technology (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1021/acs.joc.4c01421
- Citations
- 3
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Recruitment Program of Global Experts
- Project 211
- Fundamental Research Funds for the Central Universities