CTGF, FN1, IL-6, THBS1, and WISP1 genes and PI3K-Akt signaling pathway as prognostic and therapeutic targets in gastric cancer identified by gene network modeling
A mutual interplay emerged, where PI3K-Akt signaling could upregulate certain genes, forming feedback loops and intensifying cancer phenotypes. The interconnected overexpression of genes and the PI3K-Akt pathway fosters gastric tumorigenesis, suggesting therapeutic potential. DrugBank analysis identified limited FDA-approved drugs, advocating for further exploration while targeting these hub genes could reshape GC treatment. The identified genes could be novel diagnostic/prognostic biomarkers or potential therapeutic targets for GC, but further clinical validation is required.
Authors
- Abozar Ghorbani (ORCID: https://orcid.org/0000-0002-2183-0033)
- Hamed Montazeri (ORCID: https://orcid.org/0000-0001-8532-4327)
- Negar Mottaghi-Dastjerdi (ORCID: https://orcid.org/0000-0001-8386-774X)
- Fateme Yazdani
- Mohammad Soltany‐Rezaee‐Rad (ORCID: https://orcid.org/0000-0002-0663-1140)
- Farzane Khoshdel
- Babak Goodarzy (ORCID: https://orcid.org/0009-0007-4409-5936)
- Shirin Salehi
Institutions
- Atomic Energy Organization of Iran (IR)
- Iran University of Medical Sciences (IR)
- Farzan Knowledge Development, Research and Technology Institute (IR)
- Nuclear Science and Technology Research Institute
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Discover Oncology
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1007/s12672-024-01225-4
- Citations
- 15
- Primary Topic
- Connective Tissue Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 3.51
Funders
- Iran University of Medical Sciences