GUT AND SKIN MICROBIOME IN PATIENTS WITH HIDRADENITIS SUPPURATIVA

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that profoundly diminishes the quality of life for the affected patients, and is characterized by persistent purulent lesions in anatomical areas prone to constant skin friction, such as the armpits, groin, buttocks and breasts. The HS pathophysiology encompasses an array of factors, such as inflammation, genetics, the microbiome of the patient, and environmental components to name a few. Although it has been implicated that the patient microbiome is one of the factors in the pathogenesis of HS, the precise connection between the commensals and the host still remains to be fully researched. The studies examined in this review note that Porphyromonas, Peptoniphilus and Prevotella spp were observed in the skin microbiome of the patients with hidradenitis suppurativa, along with the decrease in Cutibacterium. The increase of certain bacterial species, such as Robinsoniella peoriensis, Bilophila, Holdemania, and Ruminococcus callidus was also observed when comparing gut microbiomes of the healthy subjects to those with hidradenitis suppurativa, suggesting that these microorganisms may be involved in the pathophysiology of HS. However, the specific mechanisms that regulate the interaction between the gut and skin microorganisms remain unclear. Therefore, the purpose of this review is to analyze the recent results from skin and microbiome studies related to hidradenitis suppurativa.