Loss of TGFβ-Mediated Repression of Angiopoietin-2 in Pericytes Underlies Germinal Matrix Hemorrhage Pathogenesis
This study demonstrates that TGFβ-mediated ANGPT2 repression in pericytes is critical for maintaining blood-brain barrier integrity and identifies pericyte-derived ANGPT2 as an important pathological target for GMH-IVH.
Authors
- Junichi Saito (ORCID: https://orcid.org/0000-0002-4297-727X)
- Praveen Ballabh (ORCID: https://orcid.org/0000-0002-2387-3942)
- Jui M. Dave (ORCID: https://orcid.org/0000-0002-5448-4798)
- Raja Chakraborty
- Aglaia Ntokou (ORCID: https://orcid.org/0000-0002-5272-580X)
- Kathleen A. Martin (ORCID: https://orcid.org/0000-0002-1748-0034)
- Alex Adusei Agyemang (ORCID: https://orcid.org/0009-0003-9956-9175)
- Daniel M. Greif (ORCID: https://orcid.org/0000-0002-9842-3751)
Institutions
- Albert Einstein College of Medicine (US)
- Yale University (US)
- Cardiovascular Research Center (BR)
Publication Details
- Journal
- Stroke
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1161/strokeaha.123.045248
- Citations
- 12
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- American Heart Association
- Yale University
- Northwestern University
- Yeshiva University
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases