THE ANALYSIS STUDY OF DIAGNOSTIC ACCURACY OF SINGLE SAMPLE RULE-OUT OF HIGH-SENSITIVITY CARDIAC TROPONIN IN DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION IN EMERGENCY DEPARTEMENT: A COMPREHENSIVE SYSTEMATIC REVIEW FROM LABORATORY DEPARTMENT

Background: High-sensitivity cardiac troponin (hs-cTn) assays has significantly enhanced the diagnostic of acute myocard infark (AMI). Recent studies have shown that hs-cTn assays can effectively rule out AMI with a single sample. This systematic review aim to evaluate the diagnostic accuracy of single sample rule-out of high-sensitivity cardiac troponin in diagnosis of acute myocardial infarction in emergency departement based on literatures of the last 10 years. Methods: The study adhered to PRISMA 2020 standards, examining English literature from 2014 to 2024. It excluded editorials, reviews from the same journal, and submissions without a DOI. PubMed, SagePub, SpringerLink, and Google Scholar were utilized as literature sources. Result: Initially retrieving 360 articles from online databases (PubMed, SagePub, SpringerLink and Google Scholar) eight relevant papers were selected after three rounds of screening for full-text analysis. Conclusion: High-sensitivity cardiac troponin I assays enable rapid AMI rule-out in emergency departments, offering high sensitivity and negative predictive value. However, caution is needed when ruling in AMI, and further research is required to optimize their use.