Rejuvenating bone marrow hematopoietic reserve prevents regeneration failure and hepatic decompensation in animal model of cirrhosis
These findings suggest that loss of BM-HSCs reserve underlies the compromised innate immune function of the liver, drives regeneration failure, and the onset of non-acute decompensation. We further provide the proof-of-concept that rejuvenating BM-HSC reserve can serve as a potential therapeutic approach for preventing regeneration failure and transition to decompensated cirrhosis.
Authors
- Chhagan Bihari (ORCID: https://orcid.org/0000-0001-5801-9458)
- Prakash Baligar (ORCID: https://orcid.org/0000-0002-0553-4090)
- Nidhi Nautiyal (ORCID: https://orcid.org/0000-0001-5517-337X)
- Shiv Kumar Sarin (ORCID: https://orcid.org/0000-0002-0544-5610)
- Subhrajit Biswas (ORCID: https://orcid.org/0000-0001-5649-364X)
- Dhananjay Kumar (ORCID: https://orcid.org/0000-0002-1710-7053)
- Deepanshu Maheshwari (ORCID: https://orcid.org/0000-0003-0581-6220)
- Manisha Bhardwaj (ORCID: https://orcid.org/0000-0003-2366-2675)
- E Pranshu Rao (ORCID: https://orcid.org/0000-0003-4519-1640)
- Dinesh Mani Tripathi (ORCID: https://orcid.org/0000-0003-0897-6959)
- Anupama Kumari (ORCID: https://orcid.org/0000-0003-0579-5706)
- Sujata Mohanty (ORCID: https://orcid.org/0000-0002-1444-7191)
- Anupam Kumar
- Sandeep Kumar
- Sunidhi Diwakar
Institutions
- Amity University (IN)
- Institute of Liver and Biliary Sciences (IN)
- Institute of Molecular Medicine (IN)
- All India Institute of Medical Sciences (IN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-12
- DOI
- https://doi.org/10.3389/fimmu.2024.1439510
- Citations
- 2
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.74