Age and sex specific thresholds for risk stratification of cardiovascular disease and clinical decision making: prospective open cohort study
This study quantified the potential gains in cardiovascular disease-free life years when implementing prevention strategies based on age and sex specific risk thresholds instead of a fixed risk threshold for allocation of statin treatment. Such gains should be weighed against the costs of treating more younger people with statins for longer.
Authors
- Angela Wood (ORCID: https://orcid.org/0000-0002-7937-304X)
- Matthew Sperrin (ORCID: https://orcid.org/0000-0002-5351-9960)
- Emanuele Di Angelantonio (ORCID: https://orcid.org/0000-0001-8776-6719)
- Matthew Arnold (ORCID: https://orcid.org/0000-0001-6339-1115)
- Juliet A. Usher‐Smith (ORCID: https://orcid.org/0000-0002-8501-2531)
- Lisa Pennells (ORCID: https://orcid.org/0000-0002-8594-3061)
- Lois G. Kim (ORCID: https://orcid.org/0000-0002-4552-3820)
- Ryan Chung (ORCID: https://orcid.org/0000-0001-6545-4669)
- Zhe Xu (ORCID: https://orcid.org/0000-0003-1519-6707)
- Stephen Kaptoge (ORCID: https://orcid.org/0000-0002-1155-4872)
Institutions
- University of Cambridge (GB)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- British Heart Foundation (GB)
- National Institute for Health and Care Research (GB)
- Human Technopole (IT)
- Health Data Research UK (GB)
Publication Details
- Journal
- BMJ Medicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1136/bmjmed-2023-000633
- Citations
- 3
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Dell EMC
- Scottish Government
- National Institute for Health and Care Research
- British Heart Foundation
- Department of Health and Social Care
- Public Health Agency
- Public Health England
- China Scholarship Council
- Chief Scientist Office, Scottish Government Health and Social Care Directorate
- Medical Research Council
- Engineering and Physical Sciences Research Council
- Economic and Social Research Council
- Science and Technology Facilities Council
- Health and Social Care Research and Development Division
- NIHR Cambridge Biomedical Research Centre