Metabolic reprogramming of poly(morpho)nuclear giant cells determines glioblastoma recovery from doxorubicin-induced stress
These data demonstrate the cooperative pattern of GBM recovery from DOX-induced stress and the crucial role of metabolic reprogramming of PGCs in this process. Metabolic reprogramming enhances the efficiency of self-defense systems and increases the DOX retention capacity of PGCs, potentially reducing DOX bioavailability in the proximity of SECs. Consequently, the modulation of PGC metabolism is highlighted as a potential target for intervention in glioblastoma treatment.
Authors
- Damian Ryszawy (ORCID: https://orcid.org/0000-0003-4190-9109)
- Sławomir Lasota (ORCID: https://orcid.org/0000-0002-9477-5338)
- Maciej Pudełek (ORCID: https://orcid.org/0000-0002-1893-3066)
- Zbigniew Madeja (ORCID: https://orcid.org/0000-0002-5523-1215)
- Jarosław Czyż (ORCID: https://orcid.org/0000-0001-6779-7630)
- Katarzyna Piwowarczyk (ORCID: https://orcid.org/0000-0002-2292-8948)
- Sylwia Kędracka–Krok (ORCID: https://orcid.org/0000-0002-0466-3907)
Institutions
- Jagiellonian University (PL)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1186/s12967-024-05541-9
- Citations
- 4
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 1.30
Funders
- Narodowe Centrum Nauki
- Narodowym Centrum Nauki
- Ministerstwo Edukacji i Nauki
- Uniwersytet Jagielloński w Krakowie