Spike Protein of SARS-CoV-2 Activates Cardiac Fibrogenesis through NLRP3 Inflammasomes and NF-κB Signaling
S1 protein activates human CFs by priming NLRP3 inflammasomes through NF-κB signaling in an ACE2-dependent manner.
Authors
- Satoshi Higa (ORCID: https://orcid.org/0000-0002-5735-6249)
- Lekha Rethi
- Yu‐Hsun Kao (ORCID: https://orcid.org/0000-0001-8687-5091)
- Yi‐Jen Chen (ORCID: https://orcid.org/0000-0001-7224-4491)
- Huynh Van Tin
Institutions
- Tomishiro Central Hospital (JP)
- Wan Fang Hospital (TW)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Cells
- Published
- 2024-08-11
- DOI
- https://doi.org/10.3390/cells13161331
- Citations
- 11
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.57
Funders
- Taipei Medical University
- National Science and Technology Council
- Wan Fang Hospital