Identification of Corin and Procalcitonin in Endometrial Flushing Fluid Between Women with Polycystic Ovary Syndrome, Endometrioma, Unexplained Subfertility, and Fertile Healthy Women

Objective: Endometrial receptivity is a critical factor in achieving successful implantation; however, the precise molecular mechanisms underlying this process remain unclear.This study aimed to assess and compare the levels of corin and procalcitonin in the endometrial flushing fluid among women with unexplained infertility, polycystic ovary syndrome (PCOS), endometrioma, and fertile healthy women in relation to endometrial receptivity. Methods:A study was undertaken on a cohort of women aged 20 to 40 from January 2013 to June 2015.The study cohort comprised 20 women diagnosed with unexplained subfertility, 20 women diagnosed with PCOS, and 20 women diagnosed with endometrioma.Additionally, a control group of 20 healthy fertile women was included.Corin and procalcitonin levels were assessed in endometrial flushing fluid from all patients during the implantation window, and compared between the different groups.Results: Mean levels of corin (ng/mL) were 0.45, 0.54, 0.46, and 0.49 for PCOS, unexplained subfertility, endometrioma, and control groups, respectively (p=0.341).Mean levels of Procalcitonin (pg/mL) were 76.79, 112.21, 75.57, and 90.41 for PCOS, unexplained subfertility, endometrioma, and control groups (p=0.098).The corin and procalcitonin levels were seen to be lower in the PCOS and endometriosis groups in comparison to the control group.Nevertheless, this difference did not achieve statistical significance. Conclusion:Understanding the molecular and biochemical aspects of endometrial receptivity can provide valuable insights for diagnosis and treatment.Further research is needed to elucidate the underlying mechanisms and establish the clinical relevance of corin and procalcitonin for endometrial receptivity.