Air pollution amyloidogenesis is attenuated by the gamma‐secretase modulator GSM‐15606
Gamma-secretase modulator (GSM-15606) attenuates the amyloidogenic amyloid beta (Aβ)42 peptide during exposure to air pollution, which may be a mechanism by which air pollution increases Alzheimer's disease (AD) risk. AD drug treatments may also consider Aβ homeostasis among the chronic effects of GSM-15606 and other amyloid reduction treatments on secretase enzymes.
Authors
- José A. Godoy-Lugo (ORCID: https://orcid.org/0000-0003-4671-3201)
- Constantinos Sioutas
- Rudolph E. Tanzi (ORCID: https://orcid.org/0000-0002-7032-1454)
- Kevin D. Rynearson (ORCID: https://orcid.org/0000-0002-6490-4792)
- Caleb E. Finch (ORCID: https://orcid.org/0000-0002-7617-3958)
- Max A. Thorwald
- Ararat Chakhoyan (ORCID: https://orcid.org/0000-0001-9447-495X)
- Mafalda Cacciottolo (ORCID: https://orcid.org/0000-0003-3093-0535)
- Carla D’Agostino
Institutions
- University of Southern California (US)
- Harvard University (US)
- University of California San Diego (US)
- Massachusetts General Hospital (US)
- Capricor Therapeutics (United States) (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1002/alz.14086
- Citations
- 6
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 1.89
Funders
- Cure Alzheimer's Fund
- National Institutes of Health