Comprehensive analysis of paraspeckle-associated gene modules unveils prognostic signatures and immunological relevance in multi-cancers
This study demonstrates that SFPQ, DDX39B, and UBAP2 are significantly associated with poor prognosis in HCC, likely due to their roles in promoting angiogenesis and immune suppression. These findings highlight the potential of paraspeckle genes as prognostic biomarkers and therapeutic targets, offering new avenues for personalized treatment strategies in HCC. Further research into their functional mechanisms and clinical applicability is crucial for advancing HCC treatment and improving patient outcomes.
Authors
- Wei Zhang (ORCID: https://orcid.org/0000-0002-6190-3129)
- Guowei Yang (ORCID: https://orcid.org/0000-0002-3090-6677)
- Minfeng Shu (ORCID: https://orcid.org/0000-0003-0514-1892)
- Bowen Yin (ORCID: https://orcid.org/0000-0001-7974-3445)
- Xiaodan Ye
- Zhuoyang Fan
- Rong Liu (ORCID: https://orcid.org/0000-0001-5170-6474)
- Ming Li (ORCID: https://orcid.org/0000-0003-0273-6217)
- Xiaochen Chen (ORCID: https://orcid.org/0000-0002-0426-9547)
- Hong Han (ORCID: https://orcid.org/0000-0001-6972-2851)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1007/s12672-024-01188-6
- Citations
- 3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province