Dopamine Pathway and Parkinson's Risk Variants Are Associated with Levodopa‐Induced Dyskinesia
This study suggests that variants implicated in PD and in the dopaminergic transmission pathway play a role in the risk/time to develop LID. Further studies will be necessary to examine how these findings can inform clinical care. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Tainá M. Marques (ORCID: https://orcid.org/0000-0001-6098-2817)
- Uladzislau Rudakou (ORCID: https://orcid.org/0000-0002-1411-7985)
- Jean‐Christophe Corvol (ORCID: https://orcid.org/0000-0001-7325-0199)
- Ignacio Álvarez (ORCID: https://orcid.org/0000-0002-8537-3935)
- Ryan J. Uitti (ORCID: https://orcid.org/0000-0001-8113-4710)
- Farnaz Asayesh
- Clarissa P. C. Gomes (ORCID: https://orcid.org/0000-0003-0269-6470)
- Pablo Mir (ORCID: https://orcid.org/0000-0003-1656-302X)
- David K. Simon (ORCID: https://orcid.org/0000-0003-4793-0574)
- Zbigniew K. Wszołek (ORCID: https://orcid.org/0000-0001-5487-1053)
- Lukas Pavelka (ORCID: https://orcid.org/0000-0002-7721-3317)
- Pau Pástor (ORCID: https://orcid.org/0000-0002-7493-8777)
- Alexey Kolodkin (ORCID: https://orcid.org/0000-0002-7466-5027)
- Bart Ferwerda (ORCID: https://orcid.org/0000-0002-7050-5931)
- Jennifer A. Ruskey (ORCID: https://orcid.org/0000-0002-6392-5014)
- Sulev Kõks (ORCID: https://orcid.org/0000-0001-6087-6643)
- Jacobus J. van Hilten (ORCID: https://orcid.org/0000-0002-7030-0362)
- Sara Bandrés‐Ciga (ORCID: https://orcid.org/0000-0003-0056-1361)
- Johann Faouzi (ORCID: https://orcid.org/0000-0003-0542-9968)
- Pilar Gómez‐Gil (ORCID: https://orcid.org/0000-0003-1550-6218)
- Yuri L. Sosero (ORCID: https://orcid.org/0000-0002-9385-3920)
- Łukasz Milanowski (ORCID: https://orcid.org/0000-0003-4197-8518)
- Rob M. A. de Bie (ORCID: https://orcid.org/0000-0001-5267-0784)
- Shirley W. Eberly (ORCID: https://orcid.org/0009-0005-2338-2499)
- Lynne Krohn (ORCID: https://orcid.org/0000-0001-6554-1666)
- Patrick May (ORCID: https://orcid.org/0000-0001-8698-3770)
- Peter Heutink (ORCID: https://orcid.org/0000-0001-5218-1737)
- Owen A. Ross (ORCID: https://orcid.org/0000-0003-4813-756X)
- Eric Yu (ORCID: https://orcid.org/0000-0003-3525-4564)
- Kathryn Freeman (ORCID: https://orcid.org/0000-0002-7329-3348)
- Pille Taba
- Ziv Gan‐Or (ORCID: https://orcid.org/0000-0003-0332-234X)
- Hirotaka Iwaki (ORCID: https://orcid.org/0000-0002-8982-7885)
- Maria Teresa Periñan Tocino
- Dìaz R. Belloso
- Manuel Menéndez‐González (ORCID: https://orcid.org/0000-0002-5218-0774)
- Rejko Krüger (ORCID: https://orcid.org/0000-0003-4258-6241)
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Centre National de la Recherche Scientifique (FR)
- National Institutes of Health (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Inserm (FR)
- Centre Hospitalier de Luxembourg (LU)
- Universidad de Oviedo (ES)
- Murdoch University (AU)
- University of Luxembourg (LU)
- Medical University of Warsaw (PL)
- Leiden University Medical Center (NL)
- German Center for Neurodegenerative Diseases (DE)
- Jacksonville College (US)
- Sorbonne Université (FR)
- Data Tecnica International (United States) (US)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- École Nationale de la Statistique et de l'Analyse de l'Information (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Luxembourg Institute of Health (LU)
- Amsterdam Neuroscience (NL)
- National Institute of Neurological Disorders and Stroke (US)
- Pitié-Salpêtrière Hospital (FR)
- Mútua Terrassa (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Hospital Universitario Central de Asturias (ES)
- Institute on Aging (US)
- National Institute on Aging (US)
- Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
- Centre de Recherche en Économie et Statistique (FR)
- Perron Institute for Neurological and Translational Science (AU)
- Mayo Clinic in Florida (US)
- Amsterdam University Medical Centers (NL)
- Institut du Cerveau (FR)
- Hospital Universitario Virgen del Rocío (ES)
- Instituto de Investigación Sanitaria del Principado de Asturias (ES)
- McGill University (CA)
- University of Rochester (US)
- University of Tartu (EE)
- Universidad de Sevilla (ES)
- ENSAE Paris (FR)
- University of Amsterdam (NL)
Publication Details
- Journal
- Movement Disorders
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1002/mds.29960
- Citations
- 8
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.95
Funders
- Michael J. Fox Foundation for Parkinson's Research
- McGill University
- Consortium canadien en neurodégénérescence associée au vieillissement
- Canada First Research Excellence Fund
- Idorsia Pharmaceuticals
- National Institutes of Health
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke