Prevalence of and gene regulatory constraints on transcriptional adaptation in single cells
Our integrative approach identifies several putative hits-genes demonstrating possible transcriptional adaptation-to follow-up on experimentally and provides a formal quantitative framework to test and refine models of transcriptional adaptation.
Authors
- Madeline E. Melzer (ORCID: https://orcid.org/0009-0000-2607-6490)
- Ian A. Mellis (ORCID: https://orcid.org/0000-0002-6239-4821)
- Nicholas Bodkin (ORCID: https://orcid.org/0000-0001-5090-9616)
- Yogesh Goyal (ORCID: https://orcid.org/0000-0003-3502-6465)
Institutions
- Northwestern University (US)
- Aaron Diamond AIDS Research Center (US)
- Northwestern University (PH)
- Northwestern Medicine (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Columbia University (US)
Publication Details
- Journal
- Genome biology
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1186/s13059-024-03351-2
- Citations
- 11
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 2.57
Funders
- Burroughs Wellcome Fund
- University of Pennsylvania
- York University
- Genentech
- University of California, San Diego