<scp>LncRNA</scp> ‐ <i>Snhg3</i> regulates mouse hepatic glycogenesis under normal chow diet
Long noncoding RNAs (lncRNAs) are strongly associated with glucose homeostasis, but their roles remain largely unknown. In this study, the potential role of lncRNA-Snhg3 in glucose metabolism was evaluated both in vitro and in vivo. Here, we found a positive relationship between Snhg3 and hepatic glycogenesis. Glucose tolerance improved in hepatocyte-specific Snhg3 knock-in (Snhg3-HKI) mice, while it worsened in hepatocyte-specific Snhg3 knockout (Snhg3-HKO) mice. Furthermore, hepatic glycogenesis had shown remarkable increase in Snhg3-HKI mice and reduction in Snhg3-HKO mice, respectively. Mechanistically, Snhg3 increased mRNA and protein expression levels of PPP1R3B through inducing chromatin remodeling and promoting the phosphorylation of protein kinase B. Collectively, these results suggested that lncRNA-Snhg3 plays a critical role in hepatic glycogenesis.
Authors
- Heping Wang (ORCID: https://orcid.org/0000-0002-0153-478X)
- Chunmei Li
- Aijun Qiao (ORCID: https://orcid.org/0000-0001-7545-3395)
- Meixia Li (ORCID: https://orcid.org/0000-0001-9992-3275)
- Xiaoman Wang (ORCID: https://orcid.org/0000-0002-7833-6108)
- Jiahui Yang (ORCID: https://orcid.org/0000-0002-9723-5513)
- Xianghong Xie
- Xiaolu Li (ORCID: https://orcid.org/0000-0002-7868-580X)
- Yinghan Zhu (ORCID: https://orcid.org/0009-0003-6889-0134)
- Yanfang Guo
- Ebenezeri Erasto Ngowi (ORCID: https://orcid.org/0000-0003-4448-5276)
- Xiaojun Liu (ORCID: https://orcid.org/0000-0003-4672-8569)
- Fude Fang
- Zeyu Guo (ORCID: https://orcid.org/0009-0003-8633-7148)
- Hong Yao (ORCID: https://orcid.org/0009-0000-7967-8962)
- Yan Li (ORCID: https://orcid.org/0000-0002-5921-7752)
- Wei Zhao (ORCID: https://orcid.org/0009-0008-1882-8419)
- Yinliang Zhang
- Minglong Zhang
- Yiting Wang (ORCID: https://orcid.org/0009-0005-0249-2912)
- Enhui Chen (ORCID: https://orcid.org/0000-0002-7499-7400)
- Weihong Zhang
- Mingyue Gao (ORCID: https://orcid.org/0009-0001-3814-9594)
Institutions
- Shanxi Medical University (CN)
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Institute of Biophysics (CN)
- Shanghai Institute of Materia Medica (CN)
Publication Details
- Journal
- The FASEB Journal
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1096/fj.202401064r
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- National Natural Science Foundation of China
- Beijing Municipal Natural Science Foundation
- National Key Research and Development Program of China