Photoinduced Copper‐Catalyzed Enantioselective Allylic C(sp<sup>3</sup>)−H Oxidation of Acyclic 1‐Aryl‐2‐alkyl Alkenes as Limiting Substrates
Abstract Herein, we disclose a simple copper‐catalyzed method for enantioselective allylic C(sp 3 )−H oxidation of unsymmetrical acyclic alkenes, specifically 1‐aryl‐2‐alkyl alkenes. The C−H substrates are used in limiting amounts, and the products are obtained with high enantioselectivity, E / Z ‐selectivity, and regioselectivity. The method exhibits broad functional group tolerance, and E / Z ‐alkene mixtures are suitable C−H substrates. The transformation is enabled by light irradiation, which sustains the enantioselective copper catalysis by photoinduced oxidant homolysis.
Authors
- Heng‐Hui Li (ORCID: https://orcid.org/0000-0002-9090-4171)
- Søren Kramer (ORCID: https://orcid.org/0000-0001-6075-9615)
- Xuemeng Chen (ORCID: https://orcid.org/0000-0003-3024-7488)
Institutions
- Technical University of Denmark (DK)
Publication Details
- Journal
- Angewandte Chemie
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1002/ange.202413190
- Citations
- 1
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- Novo Nordisk
- Danmarks Frie Forskningsfond
- Novo Nordisk Fonden