Photoinduced Copper‐Catalyzed Enantioselective Allylic C(sp<sup>3</sup>)−H Oxidation of Acyclic 1‐Aryl‐2‐alkyl Alkenes as Limiting Substrates
Herein, we disclose a simple copper-catalyzed method for enantioselective allylic C(sp<sup>3</sup>)-H oxidation of unsymmetrical acyclic alkenes, specifically 1-aryl-2-alkyl alkenes. The C-H substrates are used in limiting amounts, and the products are obtained with high enantioselectivity, E/Z-selectivity, and regioselectivity. The method exhibits broad functional group tolerance, and E/Z-alkene mixtures are suitable C-H substrates. The transformation is enabled by light irradiation, which sustains the enantioselective copper catalysis by photoinduced oxidant homolysis.
Authors
- Heng‐Hui Li (ORCID: https://orcid.org/0000-0002-9090-4171)
- Søren Kramer (ORCID: https://orcid.org/0000-0001-6075-9615)
- Xuemeng Chen (ORCID: https://orcid.org/0000-0003-3024-7488)
Institutions
- Technical University of Denmark (DK)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1002/anie.202413190
- Citations
- 18
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 4.50
Funders
- Danmarks Frie Forskningsfond
- Novo Nordisk Fonden