S100A8/A9-activated IFNγ+ NK cells trigger β-cell necroptosis in hepatitis B virus-associated liver cirrhosis
Together, the data indicate that IFN-γ produced by NK cells induces β cell necroptosis via the S100A8/A9-RAGE-p38 MAPK axis in patients with LC and DM. Reduced levels of S100A8/A9, NK cells, and IFN-γ could be valuable for the treatment of LC with DM. Accumulation of S100A8/A9 in patients with LC may indicate the emergence of DM.
Authors
- Baohua Wang (ORCID: https://orcid.org/0000-0003-4761-2058)
- Hongyan Diao (ORCID: https://orcid.org/0000-0002-7197-4051)
- Lanjuan Li (ORCID: https://orcid.org/0000-0001-6945-0593)
- Yuting Meng (ORCID: https://orcid.org/0000-0002-0103-9914)
- Rui Cai (ORCID: https://orcid.org/0000-0002-9610-9363)
- Hong Liang (ORCID: https://orcid.org/0000-0002-5631-4266)
- Xuehui Li (ORCID: https://orcid.org/0000-0002-7495-2675)
- Zhongwen Wu (ORCID: https://orcid.org/0000-0002-4700-5605)
- Minghui Ru
Institutions
- National Clinical Research Center for Digestive Diseases (CN)
- National Clinical Research (US)
- Jinan Stomatological Hospital (CN)
- National Center for Infectious Diseases (US)
- First Affiliated Hospital Zhejiang University (CN)
- State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
- Zhejiang University (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1007/s00018-024-05365-2
- Citations
- 8
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.92
Funders
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities