Proportional Hazards Violations in Phase III Cancer Clinical Trials: A Potential Source of Trial Misinterpretation
PHVs are common across therapy types, and attempts to account for PHVs in statistical design are lacking despite the potential for results exhibiting nonproportional hazards to be misinterpreted.
Authors
- Timothy A. Lin (ORCID: https://orcid.org/0000-0003-4183-9120)
- Alexander D. Sherry (ORCID: https://orcid.org/0000-0001-5115-1691)
- Ying Yuan (ORCID: https://orcid.org/0000-0003-3163-480X)
- Ethan B. Ludmir (ORCID: https://orcid.org/0000-0002-5472-5344)
- Christine Lin (ORCID: https://orcid.org/0009-0007-8465-9038)
- Zachary R. McCaw (ORCID: https://orcid.org/0000-0002-2006-9828)
- Sonal S. Noticewala (ORCID: https://orcid.org/0000-0002-3153-0317)
- Joseph Abi Jaoude (ORCID: https://orcid.org/0000-0002-2283-4765)
- Ryan Sun (ORCID: https://orcid.org/0000-0003-1176-1561)
- Ruitao Lin (ORCID: https://orcid.org/0000-0003-2244-131X)
- Clifton D. Fuller (ORCID: https://orcid.org/0000-0002-5264-3994)
- Ramez Kouzy (ORCID: https://orcid.org/0000-0002-1521-0495)
- Molly B. El Alam (ORCID: https://orcid.org/0000-0001-5717-7024)
- Yu Shyr (ORCID: https://orcid.org/0000-0003-2086-9670)
- Alex Koong (ORCID: https://orcid.org/0000-0002-6448-5209)
- Roshal R. Patel (ORCID: https://orcid.org/0000-0002-6117-5520)
- Tomer Meirson (ORCID: https://orcid.org/0000-0002-5011-5477)
- J. Jack Lee (ORCID: https://orcid.org/0000-0001-5469-9214)
- Charles R. Thomas
Institutions
- Dartmouth College (US)
- University of North Carolina at Chapel Hill (US)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Rabin Medical Center (IL)
- Stanford Medicine (US)
- International Neuromodulation Society (US)
- Dartmouth Cancer Center
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-0566
- Citations
- 10
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 7.09
Funders
- Andrew Sabin Family Foundation
- Fund for Innovation in Cancer Informatics
- National Institutes of Health
- University of Texas MD Anderson Cancer Center
- National Cancer Institute