Proportional Hazards Violations in Phase III Cancer Clinical Trials: A Potential Source of Trial Misinterpretation

PHVs are common across therapy types, and attempts to account for PHVs in statistical design are lacking despite the potential for results exhibiting nonproportional hazards to be misinterpreted.

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Publication Details

Journal
Clinical Cancer Research
Published
2024-08-12
DOI
https://doi.org/10.1158/1078-0432.ccr-24-0566
Citations
10
Primary Topic
Statistical Methods in Clinical Trials
Type
article
Field-Weighted Citation Impact
7.09

Funders

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article

Proportional Hazards Violations in Phase III Cancer Clinical Trials: A Potential Source of Trial Misinterpretation

Timothy A. Lin, Alexander D. Sherry, Ying Yuan, Ethan B. Ludmir et al.
10 citations
Clinical Cancer Research
Statistical Methods in Clinical Trials
7.09
article

Proportional Hazards Violations in Phase III Cancer Clinical Trials: A Potential Source of Trial Misinterpretation

Timothy A. Lin, Alexander D. Sherry, Ying Yuan, Ethan B. Ludmir, Christine Lin, Zachary R. McCaw, Sonal S. Noticewala, Joseph Abi Jaoude, Ryan Sun, Ruitao Lin, Clifton D. Fuller, Ramez Kouzy, Molly B. El Alam, Yu Shyr, Alex Koong, Roshal R. Patel, Tomer Meirson, J. Jack Lee, Charles R. Thomas
article en
10 citations

Abstract

PHVs are common across therapy types, and attempts to account for PHVs in statistical design are lacking despite the potential for results exhibiting nonproportional hazards to be misinterpreted.

Clinical Cancer ResearchVol. 30(20)
Dartmouth College (US), University of North Carolina at Chapel Hill (US), Memorial Sloan Kettering Cancer Center (US), The University of Texas MD Anderson Cancer Center (US), Johns Hopkins University (US), Johns Hopkins Medicine (US), Rabin Medical Center (IL), Stanford Medicine (US), International Neuromodulation Society (US), Dartmouth Cancer Center, Vanderbilt University Medical Center (US)
Andrew Sabin Family Foundation, Fund for Innovation in Cancer Informatics, National Institutes of Health, University of Texas MD Anderson Cancer Center, National Cancer Institute
Good health and well-being
Openalex Percentile: Top 2%
Statistical Methods in Clinical Trials
7.09
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