Effects of Naphtho[2,1- <i>a</i> ]pyrene Exposure on CYP1A1 Expression: An <i>in Vivo</i> and <i>in Vitro</i> Mechanistic Study Exploring the Role of m6A Posttranscriptional Modification
This study systematically demonstrated that in addition to AhR-mediated transcriptional regulation, N21aP, had a new additional mechanism of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mrow><mml:msup><mml:mrow><mml:mi>m</mml:mi></mml:mrow><mml:mrow><mml:mn>6</mml:mn></mml:mrow></mml:msup></mml:mrow><mml:mi>A</mml:mi></mml:mrow></mml:math>-mediated posttranscriptional modification, jointly contributing to CYP1A1 expression. Given that PAHs are the metabolic substrates of CYP1A1, this study not only helps to understand the significance of environment-genetic interactions for the toxicity of PAHs but also helps to better understand the health risks of the emerging PAHs at environmental exposure levels. https://doi.org/10.1289/EHP14055.
Authors
- Xuyan Zou (ORCID: https://orcid.org/0000-0001-5378-7386)
- Di Zhang (ORCID: https://orcid.org/0000-0002-9341-9884)
- Rong Xia
- Shoulin Wang (ORCID: https://orcid.org/0000-0003-3070-7560)
- Shaozhuo Wang
- Yinyue Jiang
- Sheng Li (ORCID: https://orcid.org/0000-0002-2436-0962)
- Chao Wang (ORCID: https://orcid.org/0000-0001-8452-1214)
- Chao Chen (ORCID: https://orcid.org/0000-0002-5385-3651)
- Wen Zhang (ORCID: https://orcid.org/0000-0001-5221-2628)
- Shuyu Xu (ORCID: https://orcid.org/0000-0001-8568-0268)
- Hong Sun (ORCID: https://orcid.org/0000-0003-2135-3107)
- Jiayi Xu (ORCID: https://orcid.org/0000-0002-3916-0699)
- Xing Gong (ORCID: https://orcid.org/0009-0005-7358-905X)
- Jiemiao Shen
- Li Wang (ORCID: https://orcid.org/0000-0002-0496-9500)
Institutions
- Jiangsu Provincial Center for Disease Control and Prevention (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Environmental Health Perspectives
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1289/ehp14055
- Citations
- 3
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Nanjing Medical University