IDDF2024-ABS-0354 Impact of ethnicity and urbanization on the diversity of the gut microbiota in Southwest China
<h3>Background</h3> The gut microbiota is known to have substantial impacts on human health. Although urbanization has been documented to modify the composition of the gut microbiota, limited attention has been given to the highly diverse Chinese populations. <h3>Methods</h3> We collected stool and saliva samples from six representative ethnic groups within the Yunnan province, with individuals of each ethnicity living in remote villages with traditional lifestyles and in the provincial capital, Kunming. Through metagenomic sequencing, de novo assembling, and subsequent analyses, marked diversity and differences in the gut microbiota among these populations were unveiled, with associations to genetic factors and lifestyles. <h3>Results</h3> Our findings reveal substantial variations in gut microbiota among different ethnic groups, and demonstrate that the effects of urbanization on gut microbiota differ across ethnicities. <h3>Conclusions</h3> This highlights the complexity of the relationship between socioeconomic factors and the gut microbiota, and the limitations of generalizing findings from a limited number of communities.
Authors
- Liang Xiao (ORCID: https://orcid.org/0000-0001-9273-0331)
- Anders Albrechtsen (ORCID: https://orcid.org/0000-0001-7306-031X)
- Jianmei Liu (ORCID: https://orcid.org/0000-0002-8179-031X)
- Karsten Kristiansen (ORCID: https://orcid.org/0000-0002-6024-0917)
- Pernille Neve Myers (ORCID: https://orcid.org/0000-0002-1824-3305)
- Le Cheng (ORCID: https://orcid.org/0000-0002-4423-8585)
- Huahui Ren (ORCID: https://orcid.org/0000-0003-1154-9448)
- Jiahui Zhu (ORCID: https://orcid.org/0000-0002-4493-2083)
- Susanne Brix (ORCID: https://orcid.org/0000-0001-8951-6705)
- Xin Jin (ORCID: https://orcid.org/0000-0001-7554-4975)
- Lilan Hao
- Wen Wang (ORCID: https://orcid.org/0000-0003-3215-3020)
- Jinlong Yang (ORCID: https://orcid.org/0000-0003-1323-7755)
- Mo Han (ORCID: https://orcid.org/0009-0009-2927-9731)
- Lei Han (ORCID: https://orcid.org/0000-0001-5426-7710)
- Jonas Meisner
- Yang Sun (ORCID: https://orcid.org/0009-0004-9501-3599)
- Lan Wang (ORCID: https://orcid.org/0009-0005-3726-5701)
Institutions
- BGI Group (China) (CN)
- University of Copenhagen (DK)
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- BGI Research (CN)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Clinical Gastroenterology
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1136/gutjnl-2024-iddf.314
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00