Comparative Safety of In Utero Exposure to Buprenorphine Combined With Naloxone vs Buprenorphine Alone
There were similar and, in some instances, more favorable neonatal and maternal outcomes for pregnancies exposed to buprenorphine combined with naloxone compared with buprenorphine alone. For the outcomes assessed, compared with buprenorphine alone, buprenorphine with naloxone during pregnancy appears to be a safe treatment option. This supports the view that both formulations are reasonable options for the treatment of opioid use disorder in pregnancy, affirming flexibility in collaborative treatment decision-making.
Authors
- Yanmin Zhu (ORCID: https://orcid.org/0000-0001-6697-6450)
- Kathryn J. Gray (ORCID: https://orcid.org/0000-0002-3541-3724)
- Sonia Hernández–Dı́az (ORCID: https://orcid.org/0000-0003-1458-7642)
- Loreen Straub (ORCID: https://orcid.org/0000-0003-2623-2726)
- Mishka Terplan (ORCID: https://orcid.org/0000-0002-2489-2942)
- Krista F. Huybrechts (ORCID: https://orcid.org/0000-0001-5805-8430)
- Jonathan M. Davis (ORCID: https://orcid.org/0000-0001-5209-9768)
- Hilary S. Connery (ORCID: https://orcid.org/0000-0002-6169-3731)
- Brian T. Bateman (ORCID: https://orcid.org/0000-0001-5950-8683)
- Hendrée E. Jones (ORCID: https://orcid.org/0000-0001-6180-8642)
- Seanna Vine (ORCID: https://orcid.org/0000-0002-6908-4201)
- Barry Lester
- Heidi Zakoul (ORCID: https://orcid.org/0009-0008-3022-9013)
- Elizabeth A. Suarez (ORCID: https://orcid.org/0000-0001-8989-7878)
- Helen Mogun
Institutions
- Rutgers, The State University of New Jersey (US)
- University of North Carolina at Chapel Hill (US)
- Brigham and Women's Hospital (US)
- Tufts Medical Center (US)
- Harvard University (US)
- Providence College (US)
- University of Washington (US)
- Brown University (US)
- McLean Hospital (US)
- Women & Infants Hospital of Rhode Island (US)
- Friends Research Institute (US)
- Stanford University (US)
Publication Details
- Journal
- JAMA
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1001/jama.2024.11501
- Citations
- 11
- Primary Topic
- Prenatal Substance Exposure Effects
- Type
- article
- Field-Weighted Citation Impact
- 12.20